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Pharmacology: By in vitro and in vivo, Magnesium increase endothelium vasodilator as prostacyclin. Endothelium disfunction caused by injury effect of free radical. Magnesium protect endothelium cell from injury, so Magnesium can protect ischemic damage by Calcium changing, and as inhibition for Calcium influx into ischemic cell.
Magnesium is co-factor for several enzymes too, included energy metabolism need Magnesium as anti-convulsan which runs as competitive antagonize from Glutamat N-Metil-D-Aspartate Receptor that had epileptogenic character. As strong vasodilator, administration Magnesium for mother pre-eclampsia can increase blood flowing of brain.
